v
UPDATES
AND
ADDITIONS
Gene expression prof
ling to fl
esh
out anatomy and physiology ties in
to f
nal chapter
Chapter 3
Vignette introduces new HIV drug
Updated coverage oF the
mechanism oF osmosis
±rom Science to Technology box on
tailoring stem cells to treat disease
Chapter 4
±igure 4.20 on DNA replication
includes the cell cycle, with
reFerence to the changes in
chromosome structure that occur
during S phase
±rom Science to Technology 4.1
discusses an innocence project case
Chapter 5
New micrograph For chapter opener
(better view oF whole tissue)
Moved intercellular junctions From
chapter 3 to chapter 5 introduction
Many new micrographs and
accompanying line art
New icon For f
gure 5.12
a
salivary
glands instead oF pancreas
Chapter 6
New vignette highlights cryo-
electron tomography view oF
proteins responsible For the skin’s
integrity
Added to melanin production
(From tyrosine in melanosomes)
Moved skin color to melanin
production earlier in chapter
New micrographs and
corresponding line art, and other
new photos
Clarif
ed wound healing in the text
and f gure
Remember that although you are
working hard to successFully complete
this course, you are not doing so For
us, or even For your teacher.
You are
working For yourselves and For your
Future patients, as health care proFes-
sionals.
Your course is not so much a
hurdle as a stepping stone, even more
so a Foundation.
We have written this
book to help prepare you For success
along that path.
David Shier, Jackie Butler, Ricki Lewis
GLOBAL CHANGES
Numbered A heads easily link to
Learning Outcomes/Assessments
Introductory sections For each
chapter
Practice questions dividing sections
numbered sequentially For clearer/
easier reFerence
Added pronunciations
New and updated boxes
throughout illuminate new
technologies, including biomarkers,
reprogrammed (induced
pluripotent) stem cells, DNA
microarrays, nanotechnology, the
metabolome and microbiome,
microRNAs, brain banks, RNA
interFerence, tissue engineering,
vaccines, stem cell therapies, and
direct-to-consumer genetic testing
Chapter 1
New f gure on directional terms
Updated terminology to be
consistent with Terminologia
Anatomica
Improved shading on f
gures
depicting body cavities
FROM THE AUTHORS
In biological evolution, a successFul
species becomes the best suited that
it can be For a particular environment.
In a similar manner,
Hole’s Human
Anatomy & Physiology
continues to
evolve as a modern exploration oF the
human, From the cellular and molecu-
lar underpinnings oF the Functions oF
liFe to its interacting organ systems.
We are authors, but f
rst and Fore-
most we are teachers.
What we and
our reviewers do in class is reFlected
in each new edition. We are espe-
cially excited about the Learn, Practice,
Assess approach to this new edition.
Each chapter opens with Learning
Outcomes, contains numerous opportu-
nities to Practice throughout, and closes
with Assessments that are closely tied
to the learning outcomes.
Students have always come First
in our approach to teaching and text-
book authoring, but we now Feel more
excited than ever about the student-
oriented, teacher-Friendly quality oF this
text. We have never included detail For
its own sake, but we have Felt Free to
include extra detail iF the end result is
to clariFy.
The level oF this text is geared
toward students in two-semester
courses in anatomy and physiology
who are pursuing careers in nursing
and allied health f
elds and who have
minimal background in physical and
biological sciences. The f
rst Four chap-
ters review chemistry and physiological
processes. Students who have studied
this material previously will view it as
a welcomed review, but newcomers
will not f
nd it intimidating.
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